APIs and Intermediates

1

Afatinib

439081-18-2

Afatinib dimaleate

850140-73-7

7-Fluoro-6-nitro-4-hydroxyquinazoline

162012-69-3

N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine

162012-67-1

n-(3-chloro-4-fluorophenyl)-6-nitro-7-(((3s)-tetrahydro-3-furanyl)oxy)-4-quinazolinamine

314771-88-5

N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine

314771-76-1

(s)-(+)-3-hydroxytetrahydrofuran;(s)-(+)-tetrahydro-3-furanol

86087-23-2

trans-4-dimethylaminocrotonic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride

848133-35-7

2

Idelalisib(CAL-101)

870281-82-6

[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester

870281-85-9

(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

870281-86-0

boc-l-2-aminobutyric acid

34306-42-8

2-fluoro-6-nitro-n-phenylbenzamide

870281-83-7

2-amino-5-fluoro-n-phenylbenzamide

60041-89-6

2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

1417456-04-2

3

Tedizolid phosphate

856867-55-5

Tedizolid

856866-72-3

n-(3-fluoro-4-(6-(2-methyl-2h-tetrazol-5-yl)-3-pyridinyl)phenyl)carbamic acid phenylmethyl ester

1220910-89-3

5-bromo-2-(2-methyl-2h-tetrazol-5-yl)pyridine;2-(2-methyl-5-tetrazolyl)-5-bromopyridine

380380-64-3

(5r)-3-(4-bromo-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

444335-16-4

2-(2-methyl-2h-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester;2-(2-methyl-2h-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

1056039-83-8

4

Nintedanib (BIBF 1120)

928326-83-4

Nintedanib Ethanesulfonate Salt

656247-18-6

methyl 2-oxoindole-6-carboxylate;6-methoxycarbonyl-2-oxindole; oxindole-6-carboxylic acid methyl ester

14192-26-8

N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide

262368-30-9

N-Methyl-4-nitroaniline

100-15-2

(3e)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-1h-indole-6-carboxylic acid methyl ester

1168150-46-6

trimethyl orthobenzoate

707-07-3

5

Lesinurad（RDEA594)

878672-00-5

3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol

878671-96-6

4-Cyclopropyl-1-naphthalenamine hydrochloride (1:1)

1533519-92-4

1-cyclopropyl-4-isothiocyanatonaphthalene

878671-95-5

4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

1533519-84-4

Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate

1533519-85-5

6

Lenvatinib (E7080)

417716-92-8

Lenvatinib Mesylate

857890-39-2

4-chloro-7-methoxyquinoline-6-carboxamide

417721-36-9

1,4-dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic acid methyl ester

205448-65-3

Methyl 4-chloro-7-methoxyquinoline-6-carboxylate

205448-66-4

4-amino-3-chlorophenol

17609-80-2

7

Ibrutinib(PCI-32765)

936563-96-1

(r)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1h-pyrazolo(3,4-d)pyrimidin-4-amine

1022150-12-4

3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-4-amine

330786-24-8

3-amino-4-cyano-5-(4-phenoxyphenyl)pyrazole

330792-70-6

(S)-1-Boc-3-hydroxypiperidine

143900-44-1

8

Palbociclib (PD0332991)

571190-30-2

tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

571188-59-5

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

1013916-37-4

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

1016636-76-2

9

Macitentan

441798-33-0

4,6-dichloro-5-(4-bromophenyl)pyrimidine

146533-41-7

n-propylsulfamide;propylsulfamide

147962-41-2

n-propyl-sulfamide potassium salt

1393813-41-6

n-propylsulfamide sodium salt

1642873-03-7

10

n1-(2-(dimethylamino)ethyl)-5-methoxy-n1-methyl-n4-(4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)-1,2,4-benzenetriamine

1421372-66-8

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro-1,4-benzenediamine

1421372-67-9

n-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1h-indol-3-yl)-2-pyrimidinamine

1421372-94-2

4-fluoro-2-methoxy-5-nitroaniline

1075705-01-9

3-(2-chloro-4-pyrimidinyl)-1-methyl-1h-indole

1032452-86-0

11

Neratinib(HKI-272)

698387-09-6

3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline

524955-09-7

n-(4-chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide

848133-76-6

4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinoline

848139-78-6

12

Pazopanib

444731-52-6

Pazopanib HCL

635702-64-6

3-Methyl-6-nitroindazole

6494-19-5

2,3-Dimethyl-6-nitro-2H-indazole

444731-73-1

2,3-Dimethyl-6-amino-2H-indazole

444731-72-0

2,3-Dimethyl-2H-indazol-6-amine hydrochloride

635702-60-2

13

Ceritinib

1032900-25-6

2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

761440-16-8

5-Methyl-2-(1-methylethoxy)-4-(4-piperidinyl)benzenamine hydrochloride

1380575-45-0